Infertility among women has been widely studied by both natural and social scientists. However, the challenge persists to burden a large number of women across the globe. Whereas some scholars feel that psychotherapy can be a long-lasting solution, the exact impact of infertility is not well established, particularly among the Jordanian women. Therefore, this study was designed to explore the lived experience of Jordanian women diagnosed with infertility to model up the psychotherapeutic programs to care for the identified challenges. To do so, this research adopted a qualitative phenomenological design that involved 17 participants which were selected using nonprobability and snowball sampling approaches. The resultant qualitative data were analyzed using Colaizzi's methods of analysis and interpretation. Five major themes were identified from the collected data, and these formed the framework for interpretation and discussion. Themes include social isolation, marital instability, grief and depressive symptom, uncertainty about the future as well as faith in God and religion as coping strategies. Exposing such challenges might help to guide the intervention schemes programmed by the various counselors and psychotherapists on how to cope with the burden of infertility.